binnen zenuwstelsel aandoeningen: dementie van het frontotemporale type (FTD) amyotrophic lateral sclerosis (ALS) Motor neuron disease (MND)
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age >= 18 years, speak Dutch fluently, have a proxy (partner, family member or close friend) who speaks Dutch fluently and is willing to fill in the questionnaires. Furthermore, ALS patients must have sporadic or familial (fALS), probable, probable-laboratory supported or definite ALS, as defined by the El Escorial criteria, with a symptom duration of less than 12 months. ALS-FTD and behaviour variant-FTD patients must have sporadic or familial, probable or definite bv-FTD, as defined by the Neary criteria and the revised criteria by Rascovsky et al.
Exclusion criteria
Exclusion criteria: Any neurological or psychiatric condition with cognitive impairment or behavioural changes, use of psychopharmaca, excessive alcohol intake, i.e. >= 5 drinks per day, forced vital capacity
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| 1. An estimate of the impact of ALS and the frontotemporal syndrome on the patient and their carers. 2. A brainbank of phenotyped ALS patients. | — |
Primary
| Measure | Time frame |
|---|---|
| 1. A validated, short cognitive screening instrument for ALS patients. 2. Differences in structural and functional brain networks (connectivity measures) between patients with and without a frontotemporal syndrome. | — |
Countries
Netherlands
Outcome results
None listed