Resting state functional MRI in term neonates with perinatal asphyxia

Resting state functional MRI in term neonates with perinatal asphyxia - NEOREST

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44127

Enrollment

Registered

2013-08-06

Start date

2014-02-10

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

asphyxia cerebral damage

Interventions

None listed

Eligibility

Age

2 Years to 11 Years

Inclusion criteria

Inclusion criteria: Term neonates clinically diagnosed with perinatal asphyxia.

Exclusion criteria

Exclusion criteria: Lack of informed consent of parents (parental refusal or unable to explain because of language barrier). Neonate with known congenital malformation(s) of the brain or congenital infection of the brain. Neonate with known syndrome (e.g. Down syndrome). Neonate with known congenital neuromuscular disease.

Design outcomes

Primary

Measure	Time frame
1.Feasibility of the rs-fMRI technique will be determined by assessing the image quality of the dynamic scans, the presence of motion artefacts and the temporal SNR. 2. The intra-session reproducibility of the rs-fMRI technique in neonates with asphyxia determined by the mean and Standard Deviation (SD) of the difference between 2 rs-fMRI acquisitions of 6 minutes each of the volume of the activated set of voxels and of the signal intensity of these voxels. Bland-Altman plots and Smallest Detectable Change will be used to report this.	—

Measure

Time frame

1.Feasibility of the rs-fMRI technique will be determined by assessing the image quality of the dynamic scans, the presence of motion artefacts and the temporal SNR. 2. The intra-session reproducibility of the rs-fMRI technique in neonates with asphyxia determined by the mean and Standard Deviation (SD) of the difference between 2 rs-fMRI acquisitions of 6 minutes each of the volume of the activated set of voxels and of the signal intensity of these voxels. Bland-Altman plots and Smallest Detectable Change will be used to report this.

—

Secondary

Measure	Time frame
nvt	—

Countries

Netherlands

Outcome results