Biological variation of cardiac biomarkers in aortic valve stenosis

Biological variation of cardiac biomarkers in aortic valve stenosis - Biological variation of cardiac biomarkers in aortic valve stenosis

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44121

Enrollment

Registered

2015-07-15

Start date

2015-09-28

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic stenosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Individuals (aged * 18 years) with clinically stable moderate aortic valve stenosis, defined by serial Doppler echocardiographic measurements of maximum transvalvular velocity (Vmax), mean pressure gradient (PGmean), and Aortic Valve Area (AVA) and a preserved ejection fraction (EF), will be recruited to participate in this study. Only subjects who are able to provide informed consent will be included.

Exclusion criteria

Exclusion criteria: Subjects with severe aortic valve stenosis Subjects with clinically progressive aortic valve stenosis Subjects with documented atrial fibrillation in the last year. (subjects are allowed to have a history of atrial fibrillation) Subjects with acute myocardial infarction in the last 6 months Subjects with hospitalisation for heart failure in the last 6 months Subjects with pulmonary embolism in the last 6 months Subjects with chronic kidney disease (CKD)

Design outcomes

Primary

Measure	Time frame
Concentrations of cardiac biomarkers (eg troponins, NT-pro-BNP, ST-2 and galectin-3) measured 7 times within 1 year.	—

Secondary

Measure	Time frame
Not applicable.	—

Countries

Netherlands

Outcome results