obesitas Chronic and acute pain fibromyalgia obesity polyneuropathy
Conditions
Interventions
Alfentanil. Alfentanil is a µ-opioid receptor agonist used for the treatment of
acute pain. Using the TCI system alfentanil concentrations will be set at 100
ng/ml, 200 ng/ml in 2 groups of 10 subje
Sponsors
Leids Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Healthy subjects of either sex between the age of 18 and 75; ;Patient inclusion criteria: (i) Patients diagnosed with fibromyalgia or peripheral polyneuropathy according to the guidelines of the IASP or other professional pain societies (eg., Netherlands Society of Anesthesiologists); or patients scheduled for elective surgery with post-operative opiate treatment; (ii) a pain score of 5 or higher for chronic pain patients; (iii) age between 18 and 75 years; Obesity patients: BMI > 35
Exclusion criteria
Exclusion criteria: Medical disease such as pulmonary, renal, liver, cardiac, gastro-intestinal, vascular disease; allergy to study medication; use of strong opioids; use of benzodiazepines; raised intracranial pressure;(x) pregnancy and/or lactation
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Heat and electrical pain VAS scores | — |
Secondary
| Measure | Time frame |
|---|---|
| Questionnaires for obese patients QST values corneal confocal microscopy results conditioned pain modulation offset analgesia temporal summation | — |
Countries
Netherlands
Outcome results
None listed