Ventilator-Induced Diaphragm Dysfunction in ICU patients

Ventilator-Induced Diaphragm Dysfunction in ICU patients - Diaphragm weakness in the ICU

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON44050

Enrollment

150

Registered

2010-05-27

Start date

2010-09-01

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

aandoeningen van de ademhalingsspieren ventilator-induced diaphragm dysfunction (VIDD)

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: -Mechanically ventilated septic patients in the ICU planned for a laparotomy for suspected or proven intra-abdominal sepsis (incidence: ~50 p year), and mechanically ventilated non-septic patients in the ICU planned for a laparotomy or thoracotomy for other reasons such as trauma, abdominal haemorrhage, vascular surgery and patients scheduled for a thoracotomy for removal of a small (T1-T2) pulmonary tumor (these will serve as control subjects). -Age: >18 years -Gender: both male and female -all ethnic backgrounds

Exclusion criteria

Exclusion criteria: -COPD (GOLD stage II-IV) or CHF (NYHA class III-IV) -Neuromuscular disease -Drugs known to alter muscle structure and function -Chronic metabolic disease -Pulmonary hypertension -Chronic use of corticosteroids (defined as >7.5 mg/day for at least 3 months) ->10% weight loss within last 6 months.

Design outcomes

Primary

Measure	Time frame
Main study parameter/endpoint: •contractile force and structure of single diaphragm muscle fibers.	—

Secondary

Measure	Time frame
Secondary study parameters/endpoints: •Morphological determination of muscle fiber cross sectional area •Muscle fiber ultrastructure by electronmicrocopy •Posttranslational modification of contractile proteins •Diaphragm cytokine profile •Gene expression analysis by Affymetrix •Comparison of findings from diaphragm muscle to those from the non-respiratory rectus abdominus muscle and latissimus dorsi. •Correlation between diaphragm muscle fiber strength and the number of failed weaning trials. •Effect of duration of mechanical ventilation on contractile strength (by comparing individuals with various durations of mechanical ventilation). •Microvascular function. •Inflammation	—

Measure

Time frame

Secondary study parameters/endpoints: •Morphological determination of muscle fiber cross sectional area •Muscle fiber ultrastructure by electronmicrocopy •Posttranslational modification of contractile proteins •Diaphragm cytokine profile •Gene expression analysis by Affymetrix •Comparison of findings from diaphragm muscle to those from the non-respiratory rectus abdominus muscle and latissimus dorsi. •Correlation between diaphragm muscle fiber strength and the number of failed weaning trials. •Effect of duration of mechanical ventilation on contractile strength (by comparing individuals with various durations of mechanical ventilation). •Microvascular function. •Inflammation

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Countries

Netherlands

Outcome results