Aging - Sarcopenia Muscle loss Sarcopenia
Conditions
Interventions
From p 17 of C1 protocol document:
Exercise Training:
Participants will perform a 12-week resistance type exercise-training program,
consisting of six different exercises. Leg press, leg extension
Aging
Dietary protein
Resistance exercise
Skeletal muscle
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: * Healthy males * Age between 65 and 80 y * BMI between 18.5 and 30 kg/m2 * Moderately active, performing fitness or sports on a non-competitive basis 1 time or less than 2 hours per week
Exclusion criteria
Exclusion criteria: * HbA1C level above 6.5% * Fasted blood glucose level above 6.9 mmol/L * Celiac disease * Lactose intolerance * Smoking * Diabetes * Cancer * Cardiovascular Disease * Diagnosed GI tract diseases * Arthritic conditions * A history of neuromuscular problems * Cognitive Impairment * COPD * Renal disorder * Any medications known to affect protein metabolism (i.e. corticosteroids, non-steroidal anti-inflammatories, or prescription strength acne medications). * Participation in exercise program * Hypertension, high blood pressure that is above 140/90 mmHg.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Quadriceps CSA (CT Scan) | — |
Secondary
| Measure | Time frame |
|---|---|
| * Skeletal muscle fibre size (Muscle Biopsy) * Whole-body and regional body composition (DEXA) * Muscular strength (1 RM * each exercise machine) * Diurnal rates of muscle protein synthesis (Muscle Biopsy - Heavy water) | — |
Countries
The Netherlands
Outcome results
None listed