Role of different phosphate binders on absorption of vitamin K, metabolism of matrix *-carboxy-glutamaat (Gla) proteïne (MGP).

Role of different phosphate binders on absorption of vitamin K, metabolism of matrix *-carboxy-glutamaat (Gla) proteïne (MGP). - Vascular calcification, vitamin K, different phosphate binders and MGP

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON44005

Enrollment

Registered

2014-04-28

Start date

2014-11-03

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

vascular calcification atherosclerosis

Interventions

Randomization between calciumcarbonate and lanthanumcarbonate with collection of blood samples. Blood will be drawn from hemodialysis shunt or catheter. And after 16 weeks a period of four weeks sup

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Dialysis patients older than 18 years without the prospect of renal function recovery and life expectancy longer than six months.

Exclusion criteria

Exclusion criteria: 1 Use of vitamin K antagonists 2 Calcium under 2,1 or above 2,6 mmol/l 3 Pregnancy 4 Phosphate under 1,4 or above 2,2 mmol/l 5 Allergy or intolerance for study medication 6 PTH under 15 or above 65 pmol/l

Design outcomes

Primary

Measure	Time frame
Difference in dp-ucMGP en PIVKA-II levels after eight weeks of treatment with lanthanumcarbonate or calciumcarbonate.	—

Secondary

Measure	Time frame
Difference in dp-ucMGP and PIVKA-II levels after menaquinon suppletion.	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)