hallucinations schizophrenia
Conditions
Interventions
12 patients receive frpm the investigator in total 4 joints (two with Bediol
and two with Bedrobinol) that they smoke in the presence of the researcher on
four different days.
Cannabis
Psychosis
Schizophrenia
Side effects
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: 1. males aged 18 to 65 2. At present (almost) daily (at least 4-5 times a week) use of Dutch weed (cannabis containing THC virtually only) 3. Chronic psychotic disorder and is currently in a treatment / care program 4. According to the practitioner a suboptimal response to currently available interventions, eg, persistent psychotic symptoms, psychotic decompensations frequent and / or severe impairment in social functioning 5. Willing to smoke two medicinal cannabis variants that differ in THC / CBD ratio. On four different days one joint is smoked (two joints a variant, a total of 4 joints).
Exclusion criteria
Exclusion criteria: 1. suffering from a serious neurological or medical illness (other than schizophrenia) 2. heavy use of alcohol (> 60 gram per day) or regular use (> 2x per week) of amphetamine, cocaine or opiates
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary question is whether the participant cannabis version with 8% CBD (Bediol) from the drop wants to smoke rather than by himself so far purchased cannabis variety. Question 1. Would you take this cannabis in the sequel as a preferred alternative? Question 2. If yes. Is this because of fewer side effects when smoking this variant or other reasons? | — |
Secondary
| Measure | Time frame |
|---|---|
| 1. Experience with the cannabis just smoked (enough *high*, taste)? Different or similar to the kind you smoke normally? 2. Experiences during/after smoking the joints (less anxiety, panic, calm, drowsiness, excited, pleasant, stoned, dizziness, restlessness, lethargic, depressed or lethargic feeling, craving, sweating, nausea, dizziness, tremors, palpitations (Questionnaires see F9 + F10). | — |
Countries
The Netherlands
Outcome results
None listed