atopic ezema skin barrier impairment
Conditions
Interventions
On a small spot on their underarms the SC of subjects will be partially removed
non-invasively by taking 10 tape strips. The subjects will apply 2 g of an
emollient enriched with barrier lipids twic
Sponsors
Universiteit Leiden
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - age between 18 and 40. - Caucasian - AE is present for * 2 years - TEWL values before the start of the study are * 15 g/m2/h on non-lesional skin
Exclusion criteria
Exclusion criteria: - Abundant hear, tattoos, or lesions on the underarm - Chronically inflammatory (skin)disease, except AE; - Dermatological disorders or a history of dermatological disorders (not AE); - History of drug abuse; - Pregnancy;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters and endpoints are: the physical properties of the SC lipid matrix after barrier recovery. These are assessed as, the lipid composition (measured by liquid chromatography/mass spectrometry (LC-MS)) and lipid organization (measured by attenuate total reflectance Fourier transform infrared spectrometry (ATR FTIR)). Another pirmary study parameter is the barrier function of the skin. The transepidermal water loss will be used to determine this. A third primary parameter is the disease severity, for which (local)SCORAD and EASI will be used. | — |
Secondary
| Measure | Time frame |
|---|---|
| n.a. | — |
Countries
Netherlands
Outcome results
None listed