cardiovasculaire aandoeningen en overgewicht Cardiovascular diseases and overweight
Conditions
Interventions
None listed
Sponsors
Universitair Medisch Centrum Utrecht
Eligibility
Inclusion criteria
Inclusion criteria: children who reached the age of 8 years and who already participated to the WHISTLER and WHISTLER/Cardio study, and who's parents are willing to give informed consent to participate to this study.
Exclusion criteria
Exclusion criteria: There are no exclusion criteria. In case of current or recent (last week) infections, the second visit to obtain the blood sample will be rescheduled. (this is not applicable after may 2012, as the venipuncture has stopped).
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To study the association between fat distribution and the adipokine profile in childhood, the main study parameters consist of anthropometric parameters, namely weight, quetelet index, waist circumference, and the main outcome parameters are the adipokine concentrations and clusters of adipocytokines. Moreover, to determine the effect of adipocytokines on the vascular system, the adipokine profile is used as determinant and the main outcome parameters are the carotid IMT and vascular stiffness. In the second part of the study the main study parameters are changes in fat distribution between the age of 5 and 8 years. The main outcome parameters are the changes in Z-score IMT and distension at the age of 8 years. | — |
Secondary
| Measure | Time frame |
|---|---|
| Since the abdominal fat will be measured ultrasonographically as well, secondary study parameters will be the intra-abdominal fat and subcutaneous fat as determinants of adipokine concentration and of IMT and vascular stiffness. | — |
Countries
Netherlands
Outcome results
None listed