Sepsis
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: All the patients admitted to the ICU or internal medicine ward and given standard of care intravenous therapy of either one or both of the target antibiotic classes are included. Antibiotic initiation based on clinical suspicion of infection and/or cultured pathogens susceptible to the target drugs, initial dosage prescription, and duration of therapy are at the discretion of the attending physician. ;In order to be eligible to participate in this study, a subject must also meet all of the following criteria: * Written informed consent has been obtained from the patient or their legally authorized representative. * Receiving intravenous antibiotic therapy of the target drugs. * Suitable intravenous/intra-arterial access to facilitate sample collection. * Treatment should be aimed for at least at 3 days. * Bacterial isolates sample are obtainable before start of the target drugs.
Exclusion criteria
Exclusion criteria: * Consent not obtained. *
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Achievement of the PK/PD targets: time that free (unbound) fraction of beta-lactam concentration remains above the MIC during a dosing interval (100%*T>MIC and 100%*T>4xMIC) and for the fluoroquinolone the Area Under the concentration-time Curve for the free (unbound) fraction of above the MIC (fAUC/MIC) ratio, maximum serum concentration (fCmax) and the fCmax/MIC ratio. | — |
Secondary
| Measure | Time frame |
|---|---|
| Comparison of observed PK/PD indices of the individual antibiotics with the length of ICU stay and sickness severity scores in ICU patients. | — |
Countries
Netherlands
Outcome results
None listed