influence of preload on repolarization (iPORT)

influence of preload on repolarization (iPORT) - iPORT (influence of preload on repolarization)

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43942

Enrollment

Registered

2016-02-24

Start date

2016-05-18

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

heart rhythmdisorders repolarization dependent ventricular arrhythmias

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria: * *18 years of age * Structural normal heart based on present clinical information (echocardiography, electrocardiogram) * Indication for an electrophysiological procedure based on a narrow complex tachycardia (presumed); o Concealed bypass o Atrioventricular node re-entry tachycardia (AVNRT) o Ectopic atrial tachycardia

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study:;* Use of anti-arrhythmic medication * Atrial fibrillation at time of the stimulation protocol. * Any possibility of electrical remodelling of the ventricle; o The presence of an antidrome circle tachycardia; Wolf Parkinsson White syndrome (as due to the pre-excitation of the ventricles over the bypass some ventricular electrical remodelling can be expected). o History of persistent atrial fibrillation (AF); due to persistent AF the ventricles are stimulated irregularly and aberrant conduction could induce electrical remodelling of the ventricle. o History of frequent ventricular extrasystoli.;Exclusion criteria after informed consent is signed; o At time of the electrophysiological procedure an on-going narrow complex tachycardia (as this will intervene with the stimulation protocol and will make the ecg*s unsuitable for STV QT analysis). o During the stimulation protocol a large number of ventricular extra systoles (*5) or any other reason making the ecg*s unsuitable for STV QT analysis (e.g. movement artefacts)

Design outcomes

Primary

Measure	Time frame
The main study parameter is beat to beat variability of repolarization (BVR) measured as short term variability of the QT interval (STV QT) of 31 consecutive beats on a 12-leads surface ecg.	—

Secondary

Measure	Time frame
not applicable.	—

Countries

Netherlands

Outcome results