Postprandial bile acid metabolism in the brain

Postprandial bile acid metabolism in the brain - Bile acids in the brain

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43907

Enrollment

Registered

2012-10-09

Start date

2013-06-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

impaired glucose tolerance type 2 diabetes mellitus

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Scheduled to undergo planned lumbar puncture. Age 18 +, ability to give consent, BMI 19-30, normal liver and renal function

Exclusion criteria

Exclusion criteria: - Acutely ill - DM2 (defined as HbA1C > 48 mmol/mol) - Use of medication that influences BA metabolism (ursochol, colesevelam, colestimide, statins) - History of allergy or intolerance to one of the components of the standard meal - Alcohol use >2 units per day

Design outcomes

Primary

Measure	Time frame
bile acid levels in CSF (fasted vs fed)	—

Secondary

Measure	Time frame
plasma insulin, glucose and bile acid levels, GLP-1 levels.	—

Countries

Netherlands

Outcome results