depression major depressive disorder
Conditions
Interventions
Obermann et
al., 2011). Firstly, the resting motor threshold (rMT) will be defined in each
subject as the minimal stimulation intensity evoking an MEP of >= 0.05 mV in 50%
of the trials in the musc
Sponsors
Psychiatrie
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: • Males and females above 18 years of age • First or recurrent unipolar major depressive disorder without psychotic symptoms (DSM-IV), with a chronic course during the last two years • Treatment resistance for at least two antidepressants treatment and a form of psychotherapy.
Exclusion criteria
Exclusion criteria: Presence of a current or past relevant somatic or neurological disorder A comorbid diagnosis of bipolar disorder, schizophrenia or substance dependence disorders.;With regard to transcranial brain stimulation • Epilepsy, convulsion or seizure (TMS) • Serious head trauma or brain surgery • Large or ferromagnetic metal parts in the head (except for a dental wire) • Implanted cardiac pacemaker or neurostimulator • Pregnancy With regard to other experimental techniques MRI-related exclusion criteria like claustrophobia, metal in body, pacemaker, pregnancy, etc.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is the change in depressive symptoms between both groups after rTMS treatment. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoint is the change in depressive symptoms after 5 weeks and routine -outcome monitoring (ROM) parameters. | — |
Countries
Netherlands
Outcome results
None listed