Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers

Effect of Sodium NItroprusside (SNP) on R,S- and S-Ketamine-induced psychotropic side effects, hemodynamic changes and pain relief in healthy volunteers - SNIK

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43889

Enrollment

Registered

2016-06-09

Start date

2015-04-20

Completion date

Unknown

Last updated

2024-02-28

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

chronische (neuropathische) pijn Chronic Pain neuropathic pain

Interventions

Ketamine

Pain relief

Side effects

Eligibility

Age

18 Years to 64 Years

Inclusion criteria

Inclusion criteria: Male subjects, aged 18-34 years with a body mass index

Exclusion criteria

Exclusion criteria: Severe medical disease including hypertension, liver/renal disease, neurological disorders, diaphragmatic hernia/pyrosis; (history of) psychiatric or neurological disease; allergy to study medication; (history of) illicit drug abuse/alcoholism.

Design outcomes

Primary

Measure	Time frame
Psychedelic and negative effects are measured using visual analog scales ranging from 0 (no effect) to 10 cm (maximum effect) of the Bowdle and Bond & Lader questionnaires (Appendix 1A and B).11,12	—

Secondary

Measure	Time frame
Pain relief from ketamine (S vs RS) and placebo vs SNP.	—

Countries

The Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)