painful neuropathy Peripheral neuropathy
Conditions
Interventions
None listed
Sponsors
Medisch Universitair Ziekenhuis Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Subjects with Painful PN must meet all of the following inclusion criteria to be eligible for participation: a. Fulfillment of the international diagnostic criteria for snall fiber neuropathy, for painful diabetic neuropathy or for chemotherapy induced PN by taxane in breast, ovarian or prostate cancer and oxaliplatin in colon cancer. Patients with CIPN have completed their chemotherapy treatment. b. Maximal pain VAS scores must be at least 40 (range: 0 - 100) (without neuropathic pain medication; in case of use of neuropathic pain medication, the VAS-score in the past without medication to the best of patients knowledge will be used) c. Age 18 years or older. d. Each subject will receive an information leaflet and an informed consent form. Subjects must give informed consent by signing and dating an informed consent form prior to study entry. Subjects must be willing to complete all study-related activities and examination required by the protocol. e. For the control groups, maximal pain VAS scores must be less than 40, preferably
Exclusion criteria
Exclusion criteria: Concomitant diseases that might interfere with the interpretations of the results.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The presence of mutations in SCN3A, SCN6A, SCN9a, SCN10a, SCN11a genes, in addition, in those patients with small fiber neuropathy or idiopathic neuropathy without mutations in the sodium channels and high chance of a genetic origin (age at onset | — |
Secondary
| Measure | Time frame |
|---|---|
| na. | — |
Countries
Netherlands
Outcome results
None listed