prodromal phase of Alzheimer's disease Alzheimer's disease
Conditions
Interventions
All participants will take part in the same 3-day selective attention training
program. Each session will consist of computer- based or pen and paper
exercises, that involve focusing on particular t
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Diagnosis of MCI based on the latest research criteria (clinical assessment at the memory clinic): presence of at least a memory impairment, memory complaints expressed by the patient or informant, and no problems in daily life functioning - Presence of CSF biomarkers or medial temporal lobe atrophy (medial temporal lobe atrophy scale (MTA) score > 3,(Scheltens et al., 1992), indicative of an underlying AD-pathology - 60- 80 years of age - Mini Mental State Examination (MMSE) score of *23, ensuring inclusion of only mentally competent, mild MCI patients, able to understand the purpose and instructions of the study and to give informed consent
Exclusion criteria
Exclusion criteria: - Any persisting major medical conditions (for example cancer or heart disease) - Presence of psychiatric or neurological disorders (e.g.: major depression, bipolar disorder, psychotic disorders; epilepsy, multiple sclerosis or Parkinson*s Disease) - History of brain surgery, major brain trauma, or infection - Significant reductions of visual acuity (after optical correction) - Significantly reduced hearing ability (interfering with the understanding of stimuli presented during the study) - Involvement in any other cognitive or pharmaceutical intervention, aiming to improve cognition for the duration of the study
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Performance (reaction times and accuracy) on a selective attention tasks under different conditions of attention and distraction. | — |
Secondary
| Measure | Time frame |
|---|---|
| - performance on several standardized cognitive and screening tests (screening questionnaire, MMSE, memory test) | — |
Countries
Netherlands
Outcome results
None listed