congenitale aandoeningen, niet nader gespecificeerd nvt
Conditions
Interventions
Study 3 is aimed to test an intervention:
Control group: standard psychosocial care
Therapy group: short-term psychotherapeutic program.
Sponsors
Vrije Universiteit
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for samples I, II, and for sample C : First pregnancy or previous pregnancy which ended in a miscarriage before 10 weeks. Supplementary inclusion criteria sample II: Pregnancy in week 20-22 . Supplementary inclusion criteria sample III: pregnant women considered to be at higher risk of having a baby with a congenital abnormality, based on advanced ultrasonography between 14-32 weeks of gestation. Supplementary inclusion criteria for sample C a. Pregnant women who have been in contact with mental health services or child protection agencies before the age of 18, who are currently in contact with mental health care or who had one or more traumatic experience before the age of 18. b.Positive screening for depression (BDI >13) and / or positive screening for anxiety disorder (STAI > 40) on at least one timepoint during pregnancy. c. Negative screening for depression (BDI 4. b.Participants from sample 2: Absence of childhood trauma, indicated by responses to the Adult Attachment Interview (question 9), negative screening depression and anxiety on all measurements (BDI
Exclusion criteria
Exclusion criteria: Exclusion criteria for sample I, II, III and sample C: Insufficient mastery of Dutch language. Supplementary exclusion criteria for sample II, and sample C: a. prenatal diagnosis of a congenital abnormality b. Abortion or interruption of pregnancy before 24 weeks pregnancy. Supplementary exclusion criteria for Sample III: a. Pregnant women considered to be at higher risk of having a baby with a congenital abnormality, based on invasive diagnostics early in pregnancy (10-12 weeks). b. Isolated growth delay of the fetus. c. Pregnant women with possible congenital abnormality, based on ultra-sound scans at a centre of primary care, but not confirmed at the VUmc or other specialized centres. d. Previous pregnancy of a child with a congenital abnormality. e. Insufficient mastery of Dutch or English language. Supplementary exclusion criteria for sample VI: participants from sample C: child with a congenital abnormality. Participants from sample 2:one or more childhood trauma's (AAI), positive screening anxiety and depression (STAI > 40 en/ of BDI >13) and child with a congenital abnormality.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The most important dependent variable of study 1, 2 and 3 is parental self-efficacy. Study 2 and 3 are aimed to test mental representations of attachment as predictor of parental self-efficacy trajectories. The primary dependent variables of project C are parental self-efficacy, sensitivity and the quality of the attachment relationship with the child. The aim is to investigate whether unresolved trauma, anxiety and depression, are predictors for parental self-efficacy trajectories and the mother-child attachment relationship. The main outcome of Study 6 is methylation status. Follow up 2 years: study 1- the relation between parental characteristics (level and course of self-efficacy, selfcontrol and motivation) and experienced social and professional support is studied. Study 2 - tested is whether the relationship between parental characteristics (self-efficacy, selfcontrol and motivation) and changes in parental behavior is moderated by the use and perception of social and professional support. project C - tested is whether use of professional support is related to improvements in living conditions, parenting characteristics (self-efficacy, selfcontrol and motivation) and parenting behavior of at-risk mothers. Follow-up 4 years- part A: Study 1 - The primary objective of study 1 is to test whether self-regulation of both fathers and mothers is a predictor for the development of self-regulation of the child. Study 2 - The effect of parenting factors such as scaffolding and autonomy support on self-regulation of the child will be investigated. Project C: The relationship between parenting risk factors such as anxiety and depression and stress regulation on child outcomes in self-regulation will be investigated. Furthermore, In studies 1, 2 and C the effect of specific genetic polymorphisms in interaction with parenting factors on self-regulation of the child will be investigated. Follow-up 4 years- part B: Study 1 * The effects of parentin | — |
Secondary
| Measure | Time frame |
|---|---|
| Secundary dependent variables are physiological reactivity (study 2) and quality of the attachment relationship with the child (study 2 and 3), which were examined in relation tot parenting self-efficacy and attachment representations. In project C a secundary parameter is self-regulation of the child, which is studied in relationship to physiological reactivity of the mother and parental self-efficacy. An other secundary parameter is self-regulation of the child, which is studied in relationship to physiological reactivity of the mother and parental self-efficacy. In study 6, epigenetic changes will be explored in relation to attachment representation, parental sensitivity, parental self-efficacy and parental stress. Follow-up 2 years: study 1 - child outcomes (selfcontrol and behavior) are studied in relation to parental characteristics. Study 2 - a secondary paramater is child outcomes (selfcontrol and behavior). project C - a secondary paramater is the quality of the attachment relationship with the child. Follow-up 4 years: Secundary parameters are physiological reactivity (stress regulation) of the parent and child in relation to sensitivity and scaffolding of the parent in study 2 and project C. Follow-up 7 years: A secundary parameter is the child's perceived competence in the cognitive, social and motor domain. | — |
Countries
Netherlands
Outcome results
None listed