Metabolism Metabolism The metabolic process of the body
Conditions
Interventions
Subjects will first be subjected to a 2-week run-in diet consisting of products
that fit into a typical *Western* diet. Thereafter subjects will be randomly
allocated to a low glycemic load diet or
Metabolic flexibility
Nutrition
Phenotypic flexibility
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 64 Years
Inclusion criteria
Inclusion criteria: - Signed informed consent - Men and postmenopausal women: >= 50 and = 25.0 and 94 cm for males, >80 cm for females - Maximum 2.5 hours of moderate to vigorous physical activity per week (during last 3 months) - Agreeing to be informed about medically relevant personal test-results by a physician - Willing to comply to study protocol during study - Accessible veins on arms as determined by examination at screening
Exclusion criteria
Exclusion criteria: - Reported participation in another nutritional or biomedical trial three months before the pre- study examination or during the study - Blood donation in the past three months - Reported participation in night shift work two weeks prior to pre-study investigation or during the study. Night work is defined as working between midnight and 6.00 AM - Consumption of > 21 alcoholic units for males, > 14 alcohol units for females in a typical week - Reported use of any nicotine containing products in the six months preceding the study and during the study itself - Reported dietary habits: medically prescribed diet, slimming diet, vegetarian - People who are familiar with an allergy or intolerance to any of the provided food products - Reported weight loss or weight gain (10%) in the last six months prior to the pre-study screening - Clinically relevant abnormalities in clinical chemistry at screening (to be judged by the study physician) - Being an employee of Unilever or the collaborating research departments in Maastricht University Medical Centre (MUMC+) - Taking medication, which may interfere with study measurements, as judged by the responsible physician - Subjects, who do not want to be informed about unexpected medical findings, or do not wish that their treating physician is informed
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| - Delta RQ (change in the mean RQ value) before (fasted state) and at the end of the 2.5-hour clamp period. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters: - Delta RQ (change in the mean RQ value) upon a mixed meal challenge - Phenotypic flexibility markers, clustered into markers for energy/carbohydrate metabolism, protein metabolism, lipid metabolism, inflammation and vascular function, upon a mixed meal challenge - Comparison of diet-induced changes in the kinetic response to diet-induced changes in the baseline value - Phenotypic flexibility markers, clustered into markers for energy/carbohydrate metabolism, protein metabolism, lipid metabolism, inflammation and vascular function, in the fasted state - Insulin sensitivity Other study parameters: - Functional markers of cognitive and physical performance - Sleep quality, mood and quality of life - Body composition, 36-hour blood pressure, and 36-hour glycaemic response | — |
Countries
The Netherlands
Outcome results
None listed