Neurocognitive effects of low-grade glioma resection in eloquent areas

Neurocognitive effects of low-grade glioma resection in eloquent areas - Neurocognitive effects of awake surgery

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43795

Enrollment

Registered

2011-12-20

Start date

2012-01-12

Completion date

Unknown

Last updated

2024-05-06

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

brain tumor low-grade glioma

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Neuropsychological study: - Untreated or recurrent lesion in or near eloquent brain areas - At preoperative diagnosis: presumed low grade glioma - 18-65 years old - Fluent in speaking and understanding the Dutch language

Exclusion criteria

Exclusion criteria: - History of a medical, neurological or psychiatric condition known to affect cognitive functioning - (History of) substance abuse - Suffering from permanent cognitive or motor problems caused by previous surgery - Risk factors for awake surgery

Design outcomes

Primary

Measure	Time frame
1) The change and recovery in performance in the main neuropsychological domains (language, memory, attention, executive functions, visuoconstruction, praxis) as measured with standardized neuropsychological tests. 2) Change in perceived quality of life, as measured with QoL questionnaires.	—

Secondary

Measure	Time frame
For the neuropsychological study: 1) The influence of tumor characteristics (localization, histological type, pathological grade (WHO) and volume). 2) The influence of the extent of the resection. 3) The influence of (type and dose of) antiepileptic medication. 4) The influence of (type and dose of) postsurgical treatment, with either radiotherapy, chemotherapy, or both.	—

Countries

Netherlands

Outcome results