MS Multiple Sclerosis
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: For patients: 1. Patients with a Clinically Isolated Syndrome (CIS) suggestive of central nervous system demyelination involving the optic nerve, brainstem or spinal cord. 2. Age > 18 years en
Exclusion criteria
Exclusion criteria: For patients and controls: Sever co-morbidity like AIDS, cancer or other severe diseases with shortening life expectance
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Is there an association between clinical, immunological and infection parameters and progression to MS after a first event of demyelination. | — |
Secondary
| Measure | Time frame |
|---|---|
| - Are current diagnostic McDonald criteria also valid for clinically isolated syndromes in typical neurological practice (non-academic) settings? - Are certain single nucleotide polymorphisms (SNP*s) over represented in the subgroup progressing to clinically definite MS or associated with benign/aggressive courses? | — |
Countries
Netherlands
Outcome results
None listed