Psychosis schizophrenia
Conditions
Interventions
Virtual Reality set-up
Virtual environments have been developed with Unity3D software by CleVR BV. VR
is offered using the Oculus Rift HMD (first consumer version) with a resolution
of 1080x1200 per
Sponsors
Universitair Medisch Centrum Groningen
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Inclusion criteria for participants with a psychotic disorder: 1) Diagnosis of a psychotic disorder, determined by a structured interview (SCAN/ SCID/ M.I.N.I./ M.I.N.I. plus interview) in the previous three years 2) Age 18 - 65. 3) Indication of impaired social cognition by the treating therapist;Inclusion criteria healthy controls: 1) Age 18 - 65.
Exclusion criteria
Exclusion criteria: 1) An estimated IQ below 70. 2) Substance dependence. 3) Insufficient proficiency of the Dutch language. 4) Presence of a relevant psychiatric or neurological disorder such as autism, dementia, epilepsy or organic brain damage.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main goal of the pilot trial is to evaluate the feasibility and acceptability of the intervention and to evaluate and improve the intervention protocol. We will use feedback sessions questionnaires (completed by the therapist after each session) and post intervention evaluation questionnaires (for participants and for therapists), consisting of both quantitative and qualitative ratings to inquire about the intervention experience (e.g., was the treatment helpful, was it tolerable, was the number, frequency and duration of sessions appropriate). The following aspects will be examined with the questionnaires: General - Attrition rates Participants - Satisfaction with number and intensity of sessions - Satisfaction with content of sessions - Difficulty level appropriateness - Satisfaction with VR technology (e.g., software and hardware) - Experience (e.g., realism) of VR environments, avatars and narratives - Strength of therapeutic alliance - Subjective experience of training (e.g., helpfulness of training, applicability in daily life) - Advantages and disadvantages of current approach Training - Protocol fidelity - Satisfaction with number and intensity of sessions - Satisfaction with content of sessions - Difficulty level appropriateness - Satisfaction with VR technology (e.g., software and hardware) - Experience (e.g., realism) of VR environments, avatars and narratives - Strength of therapeutic alliance - Subjective experience of training (e.g., helpfulness of training, applicability in daily life) - Advantages and disadvantages of current approach | — |
Secondary
| Measure | Time frame |
|---|---|
| To explore the efficacy of the intervention, we will examine the effect of VR SCT on several domains (see table 1 for an overview), as well as behaviour and performance during VR SCT (see table 2 for an overview). Diagnostic Measures/ Symptoms - Mini International Neuropsychiatric Interview Plus (MINI-plus): A structured clinical interview, used to determine diagnoses. Used to verify PD status if a diagnosis has not been verified in the past three years. - Positive and Negative Syndrome Scale (PANSS): The PANSS is a semi-structured interview which uses self-report information and observation to assess positive symptoms (7 items), negative symptoms (7 items), and general psychopathology (16 items). - Social Interactin Anxiety Scale (SIAS): Measures social anxiety verbally and non-verbally with a 20 item questionnaire - Beck Depression Inventory (BDI): Measures the severity of depression with a questionnaire. - Green Paranoid thought Scale (GPTS): Measures two dimensions of paranoid thinking with a 20 item questionnaire: ideas of social reference and ideas of social persecution. Emotion Perception - Bell-Lysaker Emotion Recognition Task (BLERT): An computerized affect recognition task to assess differentiation between six basic emotions in others (happiness, anger, disgust, sadness surprise and fear). Participants are shown video vignettes in which an actor expresses one of the six basic emotions and asked which emotion they recognize. - Facial Expression of Emotion: Stimuli and Tests (FEEST): A computerized test which consists of 60 pictures portraying basic emotions (anger, disgust, fear, happiness, sadness or surprise), which the participant has to identify. - Empathic Accuracy Task (EAT): This task consists of ten videos of people who discuss an autobiographical emotional event. Each person depicted in the videos has watched their own video and continuously rated their emotions while telling the story on a 9-point scale. The participa | — |
Countries
Netherlands
Outcome results
None listed