Optical screening for head-and-neck-, lung- and esophageal cancer

Optical screening for head-and-neck-, lung- and esophageal cancer - N.A.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43773

Enrollment

168

Registered

2015-07-30

Start date

2015-12-07

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Neoplasmata in hoofd-halsgebied, longen en slokdarm Lungcancer throatcancer

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: In order to be eligible to participate in this study, a subject must meet all of the following criteria:;Patients with cancer: * Diagnosis of a primary, untreated 1) SCC of the oropharynx or larynx, OR 2) Lung cancer (all types and stages), OR 3) Esophageal cancer (all types and stages) * Age 18 or over * Good understanding of Dutch or English;Specialism-related patients not suspected for cancer * Diagnosis of 1) (Sino)nasal polyps OR nasal septum deviation/anomaly with an extended ENT-physical examination including fiber-optical endoscopy within the last 12 months OR 2) COPD, all stages with a CT-scan within the last 12 months OR 3) Patiënts with complaints of indigestion that underwent endoscopic examination of the esophagus * Age 50 or over * Good understanding of Dutch or English

Exclusion criteria

Exclusion criteria: A potential subject who meets any of the following criteria will be excluded from participation in this study if any of the following criteria are met:;*Cancer*-patiënts: * Prior treatment of the tumor ((chemo)radiation therapy or other) * Another type of tumor in the head and neck region (non SCC) * Recurrence of the tumor (no-primary tumor) * Patients with diagnosed HIV, CMV or Hepatitis C * Serious other illness;Specialism-related non-malignant patients: * Any suspection of (pre)malignant laesions at physical examination and clinical tests (e.g. CT-scan and endoscopy) * Clinical signs of malignancies (e.g. loss of weight and night sweats). * Patients with diagnosed HIV, CMV or Hepatitis C * Serious other illness

Design outcomes

Primary

Measure	Time frame
Optical scattering properties of buccal mucosa will be measured and compared between patients with and without distant malignancy.	—

Secondary

Measure	Time frame
Scattering properties will be related to nanostructural changes measured using electron microscopy on biopsy material (2 mm punch) taken from the site of the optical measurement.	—

Countries

Netherlands

Outcome results