Effects of propofol on microcirculation in children

Effects of propofol on microcirculation in children - Propofol and microcirculation

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43768

Enrollment

Registered

2015-02-18

Start date

2015-02-18

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

circulatie microcirculation

Interventions

None listed

Eligibility

Age

2 Years to 17 Years

Inclusion criteria

Inclusion criteria: -procedural sedation with propofol -children 8-18 years

Exclusion criteria

Exclusion criteria: no written informed consent

Design outcomes

Primary

Measure	Time frame
The main study parameter is to determine the effect of propofol on buccal and sublingual microcirculation in children. Both buccal and sublingual microcirculations will be evaluated with a CytoCam an optical spectroscopic sensor-based digital video imaging instrument (Braedius Medical BV, The Netherlands). The buccal capillary density will be quantified by mean buccal capillary density and functional capillary density (FCD). Sublingual microcirculation profile consists of blood vessel diameter (BVd), proportion of perfused vessels (PVV), perfused vessel density (PVD), microcirculatory flow index (MFI) and total vascular density (TVD). Macrocirculation will be monitored by blood pressure and heart rate and hemoglobin oxygen saturation by pulse oximetry.	—

Measure

Time frame

The main study parameter is to determine the effect of propofol on buccal and sublingual microcirculation in children. Both buccal and sublingual microcirculations will be evaluated with a CytoCam an optical spectroscopic sensor-based digital video imaging instrument (Braedius Medical BV, The Netherlands). The buccal capillary density will be quantified by mean buccal capillary density and functional capillary density (FCD). Sublingual microcirculation profile consists of blood vessel diameter (BVd), proportion of perfused vessels (PVV), perfused vessel density (PVD), microcirculatory flow index (MFI) and total vascular density (TVD). Macrocirculation will be monitored by blood pressure and heart rate and hemoglobin oxygen saturation by pulse oximetry.

—

Countries

Netherlands

Outcome results