Photoacoustic detection and monitoring of synovitis in finger joints with rheumatoid arthritis.

Photoacoustic detection and monitoring of synovitis in finger joints with rheumatoid arthritis. - Photoacoustic detection of rheumatoid arthritis.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43735

Enrollment

Registered

2013-04-29

Start date

2013-07-03

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Rheumatoid Arthritis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: * Men and women of 18 years and older that are fully competent to give informed consent first phase: * Patients with at least one proximal interphalangeal joint with clinically evident inflammation, significant joint effusion, hypertrophy (referred by their rheumatologist ) and a postive power Doppler score.

Exclusion criteria

Exclusion criteria: * Patients with a cardiovascular disease * Patients with bloody discharge, ulcers or wounds on the hands. * Patients with a history of non-RA related injuries/ surgeries in the joints of interest. * Patients lacking a good general health. * Patients who suffer from tremors. * Patients who are incompetent to give informed consent

Design outcomes

Primary

Measure	Time frame
The main study parameter/endpoint is the feasibility of finding structural markers for RA with photoacoustic imaging. These structural markers can, for a part, be compared with conventional methods such as physical examination and ultrasound imaging. We expect to see the known physical differences (literature) that are encountered in RA such as edema, hypertrophy and a synovial membrane that is thickened and which has an increased vascularity.	—

Measure

Time frame

The main study parameter/endpoint is the feasibility of finding structural markers for RA with photoacoustic imaging. These structural markers can, for a part, be compared with conventional methods such as physical examination and ultrasound imaging. We expect to see the known physical differences (literature) that are encountered in RA such as edema, hypertrophy and a synovial membrane that is thickened and which has an increased vascularity.

—

Secondary

Measure	Time frame
From the obtained parameters of the fase 1 research we will define new specifications for a new generation of imaging device and improve the new image processing algorithms.	—

Countries

Netherlands

Outcome results