diabetes mellitus
Conditions
Interventions
Before hospitalisation patients will be informed about the study. Informed
consent will be obtained the day before surgery. The participants will be
randomized to one of the three treatment groups:
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Signed informed consent * known diabetes mellitus type II for > 3 months * aged 18-75 years * scheduled for elective non-cardiac surgery
Exclusion criteria
Exclusion criteria: * Oral corticosteroid use - Insulin dose > 1IE/kg/day * Planned for day-care (ambulant) surgery * Planned ICU stay post-operatively * History of chronic pancreatitis or idiopathic acute pancreatitis * Impaired renal function defined as serum-creatinine * 133 *mol/L for males and * 115 *mol/L for females * Females of child bearing potential who are pregnant, breast-feeding or intend to become pregnant or are not using adequate contraceptive methods (adequate contraceptive measures as required by local law or practice) * Known or suspected allergy to trial product(s) or related products * Any condition that the local investigator feels would interfere with trial participation or the evaluation of results Planned bowel surgery
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The difference in median glucose between the GIK + BR and LG group 1 hour after surgery | — |
Secondary
| Measure | Time frame |
|---|---|
| * The difference in insulin administration during the trail between the GIK, BR and LG group * The difference in median glucose between the GIK, BR and LG group 1 hour, 4 hours and 1 day after surgery * The difference in proportion of any postoperative complication within the first month. * The occurrence of mild and severe hypoglycaemia (glucose 5.0 mmol/l) | — |
Countries
Netherlands
Outcome results
None listed