Study of the relation between biomarker patterns and the incidence of recurrent coronary events during 1-year follow-up in patients who were hospitalised for an acute coronary syndrome; BIOMarker Study to identify the Acute risk of a Coronary Syndrome (BIOMArCS)

Study of the relation between biomarker patterns and the incidence of recurrent coronary events during 1-year follow-up in patients who were hospitalised for an acute coronary syndrome; BIOMarker Study to identify the Acute risk of a Coronary Syndrome (BIOMArCS) - BIOMArCS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43706

Enrollment

900

Registered

2007-08-16

Start date

2008-01-01

Completion date

Unknown

Last updated

2024-06-18

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

coronary artery disease

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - At least 40 years of age -A high-risk profile with regard to the occurrence of primary endpoint during follow-up, as indicated by the presence of at least 2 points. 2 Points are given in case of presence of one the following risk factors: Age * 75 years, diabetes mellitus, prior angina, prior myocardial infarction, prior cerebrovascular disease, peripheral arterial disease. 1 Point is given in case of presence of one the following risk factors: Age > 65 years in men and > 70 years in women, Hypertension, Hypercholesterolemia, Current smoking, Microalbuminuria

Exclusion criteria

Exclusion criteria: - Myocardial ischemia precipitated by a condition other than atherosclerotic coronary artery disease - Severely-impaired left ventricular function or end-stage congestive heart failure NYHA-class III or IV - Severe chronic kidney disease - Co-existent condition associated with a life-expectancy

Design outcomes

Secondary

Measure	Time frame
Secondary endpoints are 1. A composite of cardiovascular mortality and non-fatal acute coronary syndrome only; 2. A composite of cardiovascular mortality, non-fatal acute coronary syndrome and all coronary revascularizations (including staged/planned procedures); 3. A composite of cardiovascular mortality, non-fatal acute coronary syndrome, unplanned coronary revascularization, re-hospitalization for angina or stroke.	—

Measure

Time frame

Secondary endpoints are 1. A composite of cardiovascular mortality and non-fatal acute coronary syndrome only; 2. A composite of cardiovascular mortality, non-fatal acute coronary syndrome and all coronary revascularizations (including staged/planned procedures); 3. A composite of cardiovascular mortality, non-fatal acute coronary syndrome, unplanned coronary revascularization, re-hospitalization for angina or stroke.

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Primary

Measure	Time frame
Primary determinants ('study parameters'): biomarkers of vascular inflammation, plaque instability and hypercoagulability The primary endpoint is a composite of cardiovascular mortality , non-fatal acute coronary syndrome or unplanned coronary revascularization due to progressive angina pectoris during 1-year follow-up.	—

Countries

Netherlands

Outcome results