Determining the possible association of skin irritation threshold and hypertrophic scar formation

Determining the possible association of skin irritation threshold and hypertrophic scar formation - Irritation threshold and hypertrophic scars

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43681

Enrollment

Registered

2013-11-27

Start date

2014-08-18

Completion date

Unknown

Last updated

2024-04-29

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

littekenhypertrofie van de huid Hypertrophic scar raised scar

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Reduction mammoplasty, at least 3 months post-operative 18 years of age or older Legally competent Patient group: scar hypertrophy in at least one of the scars Control group: all scars have remained normal (flat) during the entire post-operative period

Exclusion criteria

Exclusion criteria: Fitzpatrick photo skin type V Skin disease, skin lesions Immunological disorders Pregnancy/lactation or systemic immunosuppressive treatment during the first two years post-operatively or during the patch test

Design outcomes

Primary

Measure	Time frame
The primary study parameter is the IT as determined by visual irritation grading scale after SLS patch test.	—

Secondary

Measure	Time frame
The secondary study parameters are IL1a/IL1Ra ratios in the SC, TEWL, erythema as measured with DermaSpectrometer®, response of PBMC*s to stimulation with LPS, leukocyte numbers and cytokines in serum.	—

Countries

Netherlands

Outcome results