cognitieve stoornissen Brain metastases brain tumor
Conditions
Interventions
None listed
Sponsors
Sint Elisabeth Ziekenhuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Contrast enhanced volumetric MRI showing 1-10 newly diagnosed BM with a total tumor volume * 30cc * Lesion > 3 mm from optic apparatus* * Patient age * 18 years* * Karnofsky Performance Status * 70, WHO performance status * 2* * Anticipated survival (independent of the BM) greater than 3 months Dutch healthy control subjects will be: * Sociodemographically similar to the patient group * In good health, with no current or past psychiatric, neurologic, or cognitive disorder, and mediation-use that interferes with cognitive function
Exclusion criteria
Exclusion criteria: * No prior histologic confirmation of malignancy * Primary brain tumor, small cell lung cancer, lymphoma, leukemia, or meningeal disease * Progressive, symptomatic systemic disease without further treatment options * Prior brain radiation or surgical resection of BM * Additional history of a significant neurological or psychiatric disorder * Participation in a concurrent study in which neuropsychological testing and/or health-related QOL assessments are involved * Patients unable to complete test battery and/or study questionnaires due to any of the following reasons: lack of basic proficiency in Dutch, IQ below 85, severe aphasia, or paralysis
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| * Fatigue (MFI) * Health related QOL (FACT-BR) * Depression and anxiety (HADS) * Overall Survival * Local and distant tumor control | — |
Primary
| Measure | Time frame |
|---|---|
| * Cognitive functioning as assessed with a battery of neuropsychological tests: The revised Hopkins Verbal Learning Test (HVLT-R), WAIS Digit Span and Digit Symbol, TMT A and B, COWA, and Grooved Pegboard | — |
Countries
Netherlands
Outcome results
None listed