atherosclerosis / arteriosclerotic vascular disease
Conditions
Interventions
None listed
Sponsors
Erasmus MC, Universitair Medisch Centrum Rotterdam
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * Patient eligible for PCI of a native coronary artery * Written informed consent obtained * Study coronary artery must be accessible to the OCT /NIRS-IVUS catheters;
Exclusion criteria
Exclusion criteria: * Unable to provide informed consent * Under 18 years of age * Hemodynamic instability * Cardiogenic shock * TIMI 0 flow at target lesion site * Lesion beyond acute bends or in a location within the coronary anatomy where the catheter cannot transverse * Bypass graft as target vessel * Ejection fraction less than 30% * Contra-indication to emergency coronary artery bypass surgery * No access to cardiac surgery * Contra-indication to treatment with aspirin, ticlopidine, clopidogrel, prasugrel, ticagrelor, or heparin * Renal insufficiency (creatinine clearing
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Our primary endpoints to be investigated: 1) Association between shear stress at baseline and plaque geometry and composition at baseline (including wall thickness, cap thickness and lipids). 2) Association between shear stress at baseline and plaque geometry and composition changes over time in (including wall thickness, cap thickness and lipids). | — |
Secondary
| Measure | Time frame |
|---|---|
| 1) Association between change in plaque geometry and composition (e.g. wall thickness, cap thickness and lipids) and wall stress changes. 2) Association between change in plaque geometry and composition (including wall thickness, cap thickness and lipids) and change in shear stress. | — |
Countries
Netherlands
Outcome results
None listed