diabetes mellitus type 2 sugar disease
Conditions
Interventions
A randomized, cross-over study in which patients with T2DM and first degree
relatives will undergo a 4 week dietary intervention with normal BCAA in the
diet or to a 4 week intervention with low BCA
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Overall * Male en postmenopausal females * Age 45-70 years * Body mass index (BMI) 27 kg/m2 * Stable dietary habits (no weight loss/gain >5 kg in the last 3 months) * Stable physical activity levels for at least 6 months * Control participants without type 2 diabetes should be normal glucose tolerant (OGTT with fasting plasma glucose
Exclusion criteria
Exclusion criteria: - participants will be excluded when being diagnosed with active cardiovascular disease, diabetic foot, polyneuropathy, retinopathy - participants will be excluded when having uncontrolled hypertension - participants following a vegetarian diet or having an allergy against soya - participants with contra-indication for MRI
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary study objectives are: i) to determine whether T2DM and FDR have lower rate of leucine oxidation (umol kg-1 min-1) in muscle ii) to evaluate whether altered leucine oxidation is associated with whole body and hepatic insulin sensitivity (umol kg-1 min-1) | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study objectives are: i) to evaluate whether altered leucine oxidation is associated with mitochondrial function (pmol/mg/s) ii) to evaluate whether altered leucine oxidation is associated with the amount of liver fat (%) | — |
Countries
Netherlands
Outcome results
None listed