arterial stiffness cardiovascular risk
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Group 1 : subjects aged >18 years with asymptomatic carotid plaques as assessed by either carotid ultrasound/CT or previous MRI Group 2 : subjects aged >18 years with symptomatic carotid artery disease as evidenced by a recent TIA or ischaemic stroke in the supply area of the carotid artery in the preceding 8 months not scheduled for intervention Group 3 : healthy volunteers aged >18 years with no history of cardiovascular disease nor presence of cardiovascular risk factors
Exclusion criteria
Exclusion criteria: Exclusion criteria for all subjects • Known systemic disorders such as hepatic, renal, haematological and malignant diseases or any clinically significant medical condition that could interfere with the conduct of the study in the opinion of the investigator • Standard contra-indications to MRI based on physicians experience and current practices • Inability or unwillingness to comply with the protocol requirements, or deemed by investigator to be unfit for the study;Exclusion criteria for group 1 • Changes in dose or frequency of doses of lipid-lowering drugs, antihypertensive drugs or antidiabetic drugs in the last 6 weeks prior to baseline measurements • Cerebrovascular event in the 8 months prior to enrolment;Exclusion criteria for group 2 • Changes in dose or frequency of doses of lipid-lowering drugs, antihypertensive drugs or antidiabetic drugs in the last 6 weeks prior to baseline measurements;Exclusion criteria for group 3 • History of cardiovascular disease • Presence of risk factors for cardiovascular disease • Use of any cardiovascular medication, including but not limited to lipid-lowering therapy, antihypertensive drugs, anti-diabetic drugs, platelet aggregation inhibitors and anticoagulants
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The principal parameter is the difference in local PWV as measured by MRI at three different points in the carotid artery in (symptomatic and asymptomatic) patients with carotid plaque formation and in healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| As secondary parameters we will consider the difference in vessel wall dimensions, wall shear stress and PWV between healthy subjects and (symptomatic and asymptomatic) cardiovascular patients. | — |
Countries
Netherlands
Outcome results
None listed