hersenplasticiteit Neurogenesis
Conditions
Interventions
Subjects will be randomized to either the exercise or control group. The
subjects in the exercise group will engage in 3x weekly sessions of aerobic
exercise, whereas the control group will engage i
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Age 18-30 years - BMI * 30 kg/m2 - VO2max * 55 ml/kg/min (males), * 45 ml/kg/min (females) - Stable exercise history 3 months prior to study inclusion
Exclusion criteria
Exclusion criteria: - General contraindications for MRI (such as claustrophobia) - History of chronic renal insufficiency - History of allergic reaction to Gadolinium-containing compounds - History of any psychiatric disorder - Intensive sports (>3/week) - Excessive smoking (>1 pack/day), alcohol (>21 units/week), and other regular drug use
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| To compare the effects of 12 weeks 3x weekly aerobic exercise in healthy volunteers on: - Neurogenesis - Angiogenesis - Hippocampal function (e.g. pattern separation) | — |
Secondary
| Measure | Time frame |
|---|---|
| To compare the effect 12 weeks 3x weekly aerobic exercise in healthy volunteers on: - VO2max - Hippocampal volume - Neuronal and endothelial growth factors in serum - Neuropsychological functioning: memory and executive function - Questionnaires assessing lifestyle and dietary patterns | — |
Countries
Netherlands
Outcome results
None listed