skin barrier stratum corneum
Conditions
Interventions
None listed
Sponsors
Philips Research
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. skin type I, II or III (Fitzpatrick scale); 2. 18 - 40 years old; 3. willing to give written informed consent
Exclusion criteria
Exclusion criteria: 1. diagnosis of histamine hypersensitivity; 2. presence of cardiac pacemakers or other implanted electric devices; 3. pregnancy or lactation; 4. atopic predisposition (i.e. allergy, atopic/contact dermatitis, hay fever, asthma); 5. any current (skin) disease including conditions causing photosensitivity; 6. predisposition to respond allergic; 7. use of immunosuppressive drugs; 8. use of antihistamines drugs; 9. use of medication for hypertension with airway constricting activity; 10. use of medication with photosensitizing effects; 11. skin type IV, V, VI (Fitzpatrick scale); 12. excessive sun exposure or tanning less than 2 weeks before the beginning of the study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameters are the recovery of the skin barrier after tape stripping, measured with transepidermal water loss (marker of skin barrier status), and the clearance of inflammation after histamine iontophoresis, measured with a* value (marker of skin redness). Both measurements are non-invasive. Tape stripping and histamine iontophoresis will be performed twice on the same volunteer, on two consecutive weeks. On one occasion stimulation is followed by irradiation, in the other no irradiation is performed serving as control. | — |
Countries
Netherlands
Outcome results
None listed