kidney transplantation
Conditions
Interventions
At baseline, participants will undergo pharmacokinetic testing, a quality of
life assessment and a computerized neuropsychological test battery (the
Amsterdam Neuropsychological Tasks or ANT battery
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Age between 18-70 years Recipient of a kidney transplantation more than one year ago On a triple-low-dose immunosuppressive regimen including tacrolimus Suffering from a tremor Stable renal function Able to give informed consent
Exclusion criteria
Exclusion criteria: Not being able to understand the instructions for the tests Chronic diarrhea Use of protease inhibitors, azoles or sedatives Thyroid dysfunction Active psychiatric or neurologic disease Use of psychotropic drugs, antiepileptics or B2-agonists Excessive use of caffeine (more than 5 I.E. per day) Excessive use of alcohol (more than 2 I.E. per day)
Design outcomes
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes include (1) a selection of neuropsychological assessments from the ANT test battery, (2) tremor as measured by TETRAS (TRG Essential Tremor Rating Assessment Scale), (3) a quality of life assessment and (4) patient drug preference at the end of study. | — |
Primary
| Measure | Time frame |
|---|---|
| The primary outcome is tremor as measured by the ANT Modules Pursuit and Tracking. | — |
Countries
Netherlands
Outcome results
None listed