cardiovasculaire gezondheid, metabolde gezondheid, groei, neurodevelopment Cardiometabolic health neurodevelopmental health
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 11 Years
Inclusion criteria
Inclusion criteria: The study population comprises all children born to couples who participated in the INeS-study (registered as NL12782.018.07, METC 2007_064). The INeS-study consisted of couples seeking fertility treatment after at least 12 months of unprotected intercourse. Females were between 18 and 38 years of age and had an unfavorable prognosis for natural conception (less than 30% according to the Hunault model). Couples were diagnosed with an unexplained or mild subfertility. Couples were excluded in case of polycystic ovarian syndrome (PCOS)/anovulation, endometriosis, bilateral tubal pathology or endocrine disorders. 602 Couples were randomly allocated to three cycles of IVF-SET, six cycles of IVF-MNC or six cycles of IUI-COH. ;There were 354 children born in the INeS-study: 313 singletons, 19 twins and 1 triplet. These children were born during the 12 month follow-up period (n
Exclusion criteria
Exclusion criteria: There are no exclusion criteria.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Blood pressure at age 4-6 years | — |
Secondary
| Measure | Time frame |
|---|---|
| * General health status (including physician visits, hospital admissions, medication use) * Growth trajectory * Anthropometry (including height, weight, hip-, waist- and upper arm circumference) * Body composition (including lean body mass, fat mass, total body water) * Cardiovascular health (including arterial stiffness) * Metabolic health (including glucose and insulin levels, lipid profile, inflammatory markers) * Development and behavior | — |
Countries
Netherlands
Outcome results
None listed