DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome? -DEHUSAPS study-

DEfective HUman SAlivary gland stem cells: the cause of Primary Sjögren*s syndrome? -DEHUSAPS study- - DEHUSAPS study

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43500

Enrollment

Registered

2016-03-21

Start date

2016-04-21

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Sjögren's disease Sjögren's syndrome

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: • Presents with classic dry mouth symptoms presumed to be pSS. • Willing to have exam of oral cavity. • Scheduled for parotid biopsy for routine diagnosis and care. • Scheduled for saliva collection for routine diagnosis and care (not in controls).

Exclusion criteria

Exclusion criteria: • History of radiation therapy to the head or neck. • Another auto-immune disease, sarcoidosis, hepatitis C, IgG4 disease, HIV (all exclusion criteria for classifying a subject as pSS).

Design outcomes

Primary

Measure	Time frame
To define pSS SGSC defects using self-renewal and organoid formation techniques on pSS-derived SGSCs.	—

Secondary

Measure	Time frame
Through comparison to healthy SGSCs, transcriptome and proteome screens will unveil key pSS SGSC defects. Relating potential pSS modulators to patient biopsy banks, and chemically and/or genetically interfering with their activity will validate our findings.	—

Countries

Netherlands

Outcome results