Schilder's disease X-ALD X-linked adrenoleukodystrophy
Conditions
Interventions
None listed
Sponsors
Academisch Medisch Centrum
Eligibility
Age
2 Years to 99 Years
Inclusion criteria
Inclusion criteria: In order to be eligible to participate in this study, a patient must meet all of the following criteria: - age for which follow-up is normally recommended (2 years and older) - male patients with X-ALD (confirmed by ABCD1 mutation analysis) - MRI data available - informed consent obtained from participant or legal guardian in case of a minor;Healthy controls must meet all of the following criteria: - male sex - classmate of X-ALD patient (age matched) - informed consent obtained from participant and/or legal guardian
Exclusion criteria
Exclusion criteria: A patient (potential subject) who meets any of the following criteria will be excluded from participation in this study: - co-existing neurological disease making interpretation of acquired data difficult (for instance, multiple sclerosis) - active cerebral demyelinating disease, defined as white matter abnormalities with enhancement of the rim on MRI after intravenous gadolinium administration ;A potential control who meets any of the following criteria will be excluded from participation in this study: - neurological disease making interpretation of acquired data difficult
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is neuropsychological function. | — |
Secondary
| Measure | Time frame |
|---|---|
| The secondary study parameter is neuropsychological test data correlated to neuroimaging (MRI). | — |
Countries
Netherlands
Outcome results
None listed