antisocial behavior externalizing problems
Conditions
Interventions
This project includes two randomized, double-blind, placebo-controlled studies
with a single-dose administration of 24IU of oxytocin.
Sponsors
Radboud Universiteit Nijmegen
Eligibility
Age
12 Years to 17 Years
Inclusion criteria
Inclusion criteria: Study 1: -males -age 15-18 -no current or previous psychiatric disorder as identified by the MINI-KID -capable to read and comprehend the Dutch language -written informed consent signed by themselves and their legal representatives;Study 2: -Males -age 15-18 -antisocial behavior and conduct problems as identified by the MINI-KID -capable to read and comprehend the Dutch language -written informed consent by themselves and their legal representatives
Exclusion criteria
Exclusion criteria: -IQ lower than 75 -other severe medical problems -medication for medical problems -allergic responses to oxytocin -substance abuse -nasal surgery -nasal disease
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The main study parameter is the difference between total scores of cognitive and affective empathy as well accuracy and reaction time of emotion recognition between conditions (oxytocin/placebo administration). Additionally, we examine whether the oxytocin effect is different between traumatized and non-traumatized antisocial adolescents by comparing the scores between groups and across conditions. | — |
Secondary
| Measure | Time frame |
|---|---|
| As a secondary parameter, we explore whether total scores on psychopathic traits and dissociation can moderate the oxytocin effect on empathy and emotion recognition in healthy and antisocial male adolescents. We also measure salivary oxytocin levels to examine whether baseline and after administration peripheral oxytocin is different between antisocial adolescents with and without severe psychological trauma by comparing the oxytocin levels between groups and across conditions. | — |
Countries
Netherlands
Outcome results
None listed