Pijn, Centraal Zenuwstelsel: Verwerking van pijn. Pain
Conditions
Interventions
All subjects participate in two conditions in random sequence. These conditions
contain either sham rTMS or active 10Hz rTMS. The rTMS is 10 Hz high frequency
rTMS, stimulating the motor cortex with
Sponsors
Academisch Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: 1. Subject is or is older than 18 years. 2. Subjects should be naïve to rTMS treatment
Exclusion criteria
Exclusion criteria: 1. Subject has an condition with risk of magnetic interference while using rTMS. 2. Subject has an condition with increased or uncertain risk of inducing epileptic seizures while using rTMS(active or history of epilepsy, lesions of the brain, interfering drugs/medication) 3. Subject has an conditions with increased risk of other events while using rTMS (pregnancy, severe hearth disease) 3. Subject has an history of, clinical signs/symptoms of, or concomitant acute or chronic pain.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Analgesic effect is measured through QST. QST measurements will be performed using different modalities, e.g. mechanical pressure, electrical stimulation and conditioned pain modulation (CPM). The primary outcome is pressure pain threshold (PPT). | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary outcomes are: Electric Sensation Threshold in mA, Electric Pain Threshold in mA, Electric Pain Tolerance Threshold in mA, Conditioned Pain Modulation Paradigm in kPa for PPT and mA for EPPT and VAS-score (0-10). Mask validity tests in % (for both rTMS and sham). And Adverse events. | — |
Countries
Netherlands
Outcome results
None listed