PCOS/non-PCOS WHO 2 ovulation disorders
Conditions
Interventions
Patients will be randomized to receive one of the following two treatments:
Stair step group: blind start ovulation induction (no progesterone induced
withdrawal bleeding and stair step protocol in c
a progesterone induced withdrawal bleeding in case of
no spontaneous menses before starting an ovulation induction cycle and in
between anovulatory cycles.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: WHO classification category 2 PCOS or non-PCOS Age between 18 - 41 years Patent Fallopian tubes, proven by hysterosalpingography (HSG), a negative Chlamydia antibody titre (CAT) or diagnostic laparoscopy combined with tubal testing (DLS and TT), depending on the local protocol. BMI
Exclusion criteria
Exclusion criteria: BMI > 40 kg/m2 Previous unsuccessful ovulation induction cycles with clomiphene citrate Double-sided tubal pathology Moderate - severe male infertility (TMSC
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary endpoints are the time to pregnancy and ongoing pregnancy rate within a treatment horizon of 3 cycles. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints include time to ovulation, endometrial thickness, multiple pregnancy and the incidence of treatment failure. | — |
Countries
Netherlands
Outcome results
None listed