Standardization of brain atrophy measurement in MS patients

Standardization of brain atrophy measurement in MS patients - StandardAMS

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43474

Enrollment

Registered

2016-06-01

Start date

2016-10-20

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Multiple Sclerosis

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: MS patient group: 1. Diagnosis of relapsing-remitting, secondary progressive, or primary progressive MS. 2. 18 to 70 years old. 3. Written informed consent;Healthy controls: 1. 18 to 70 years old. 2. Written informed consent

Exclusion criteria

Exclusion criteria: 1. Inability to undergo MRI, e.g. metal objects in or around the body, claustrophobia or inability to lie still in the scanner. 2. Pregnant 3. Any (relevant) neurological disease (for healthy subjects).

Design outcomes

Primary

Measure	Time frame
Quantitative measures (median absolute difference, limits of agreement) of the inter-scanner and intra-scanner variability of measurements of the 1-year volume change of putamen, caudate nucleus, and the entire cerebrum using the new, standardised method.	—

Secondary

Measure	Time frame
The same quantitative measures of reproducibility for other, widely used methods to measure the volume change, specifically for the software Siena, FIRST and FreeSurfer.	—

Countries

Netherlands

Outcome results