Effects of BCG vaccination on immunological characteristics of hematopoetic stem cells: an explorative study

Effects of BCG vaccination on immunological characteristics of hematopoetic stem cells: an explorative study - Effects of BCG on HSC

Status

Active, not recruiting

Phases

Unknown

Study type

Interventional

Source

NL-OMON

Registry ID

NL-OMON43468

Enrollment

Registered

2016-06-23

Start date

2016-12-16

Completion date

Unknown

Last updated

2025-03-24

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

BCG vaccine tuberculosis vaccine

Interventions

Group 1: placebo vaccination. Group 2: BCG vaccination.

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: Age>18 Healthy

Exclusion criteria

Exclusion criteria: Use of systemic medication other than oral anti-contraceptive drugs Vaccination within 3 months prior to study period History of haematological disease History of malignancy Medical history of disease associated with immune deficiency Previous BCG vaccination Acute illness within 2 months prior to start of study Pregnancy Anaemia or other deviations in a complete blood count NSAID within the last 2 weeks History of claustrophobia Fastened glucose >8mmol/l

Design outcomes

Primary

Measure	Time frame
Cellular composition of the bone marrow Ex vivo differentiation of hematopoetic stem and progenitor cells Ex vivo cytokine responses of hematopoetic stem and progenitor cells	—

Secondary

Measure	Time frame
Ex vivo cytokine production of PBMCs and monocytes Gene expression profiles of hematopoetic stem cells and peripheral monocytes Epigenetic profiles relating to immune function of hematopoetic stem cells and peripheral monocytes Cellular metabolism of hematopoetic stem cells and peripheral monocytes	—

Countries

Netherlands

Outcome results

None listed

Source: NL-OMON (via WHO ICTRP)