Characterization of ascending aortic flow patterns and vessel wall in patients with aortic valve stenosis before and after surgical valve replacement: a 4D Flow Magnetic Resonance Imaging study.

Characterization of ascending aortic flow patterns and vessel wall in patients with aortic valve stenosis before and after surgical valve replacement: a 4D Flow Magnetic Resonance Imaging study. - 4D flow MRI in aortic valve stenosis and aortic dilatation.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43452

Enrollment

Registered

2016-06-27

Start date

2017-01-25

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

Aortic valve stenosis valvular heart disease.

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: We defined the following groups for inclusion: - Severe aortic stenosis (mean transvalvular gradient >40 mmHg or aortic valve area (AVA) *1.0 cm2). - Non-severe aortic valve stenosis (mean transvalvular gradiënt 1-39 mmHg and AVA >1.0 cm2). - Aortic aneurysm >45 mm (without aortic valve stenosis). - Healthy volunteers (apparently free of cardiovascular disease). ;General inclusion criteria: - Age >18 years old. - Preserved left ventricular ejection fraction (LVEF >50%). - Mentally competent. - Signed informed written consent.

Exclusion criteria

Exclusion criteria: - Age 100 bpm. - Prior cardiac/aortic surgery. - Decreased left ventricular ejection fraction (LVEF 130 kg, prior adverse reaction to gadolinium-based contrast agents). - Previous adverse reaction to gadolinium.

Design outcomes

Primary

Measure	Time frame
1. Description and quantification of blood flow parameters (e.g. flow patterns, wall shear stress, peak flow velocity) in the proximal aorta and characterization of the aortic vessel wall.	—

Secondary

Measure	Time frame
2. Aortic dimensions and quantification of aortic vessel wall microvasculature. 3. Left ventricular dimensions, function and mass.	—

Countries

Netherlands

Outcome results