aandoeningen zijn geen onderdeel van deze studie. Doel is namelijk het bepalen van humane biomarkers in urine en haar. Niet van toepassing
Conditions
Interventions
Each volunteer will be exposed orally and dermally to one of the selected
compounds.
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Good general health i.e. no use of prescribed medication (except oral contraceptives); - Age between 18 and 65 years; - BMI between 20 and 25; - Alcohol consumption less than two standard glasses a day; - Caucasian (to minimize genetic differences);
Exclusion criteria
Exclusion criteria: - Pregnancy or willing to become pregnant during the study; - Skin disorders, e.g. atopic eczema, psoriasis, or other chronic skin diseases that causes hyperkeratosis; - Skin abnormalities on the non-dominant forearm, e.g. scars and injuries; - Smoking; - Direct contact or working with pesticides;
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Concentration of parent compound(s) and/or its metabolite(s) in urine and hair after oral and dermal exposure, including relative metabolite conversion factors and recovery percentages. In addition, the excretion patterns of parents/metabolites in urine over the first 48 hours after administration will be determined. | — |
Countries
Netherlands
Outcome results
None listed