Evaluation of the cerebello-rubro-thalamic tract after (sub)thalamotomy.

Evaluation of the cerebello-rubro-thalamic tract after (sub)thalamotomy. - Evaluation (sub)thalamotomy.

Status

Active, not recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43426

Enrollment

Registered

2016-02-02

Start date

2016-02-17

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

shaking tremor

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: - Adult patients (>18 years old). - Treatment for tremor with (sub)thalamotomy in the UMCG. - Written informed consent.

Exclusion criteria

Exclusion criteria: - Contra-indications to MRI examination (e.g. heart pacemaker, metal foreign body in eye, aneurysm clip in brain, severe claustrophobia). - Implantation of DBS electrodes - Patients with a life expectancy less than 6 months - Patients physically not able to lie flat for one hour

Design outcomes

Primary

Measure	Time frame
In all patients: relation between tremor severity and localization of the lesion. Relation between clinical tremor severity and radiographic (DTI) features of the cerebello-rubro-thalamic tract. - The difference in localization of the lesioned area in the brain towards the preoperative assessed target measured in millimetres. - The volume of the dentato-rubro-thalamic tract involved in the lesioned area and compared to the contralateral side. - Tremor severity as measured by accelerometers (amplitude and frequency) and the Bain & Findley Clinical Tremor Rating Scale.	—

Measure

Time frame

In all patients: relation between tremor severity and localization of the lesion. Relation between clinical tremor severity and radiographic (DTI) features of the cerebello-rubro-thalamic tract. - The difference in localization of the lesioned area in the brain towards the preoperative assessed target measured in millimetres. - The volume of the dentato-rubro-thalamic tract involved in the lesioned area and compared to the contralateral side. - Tremor severity as measured by accelerometers (amplitude and frequency) and the Bain & Findley Clinical Tremor Rating Scale.

—

Secondary

Measure	Time frame
Patient satisfaction after (sub)thalamotomy using a short questionnaire (VAS score).	—

Countries

Netherlands

Outcome results