fysiological Thyroid function
Conditions
Interventions
The first group of 7 subjects will follow a two week course of metformin
according a specific dosing scheme. Group 2 with 7 subjects will follow a
hypocaloric diet (40% caloric restriction, high fat
Sponsors
Radboud Universitair Medisch Centrum
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: * male * No mental illness * Informed consent * Healthy, specifically no history of thyroid disease or renal insufficiency. * Aged between 18-50 years * Normal weight (BMI: 18.5-25.0 kg/m2) * Maintained stable body weight for previous 6 months
Exclusion criteria
Exclusion criteria: * Mentally incompetent * Any thyroid condition: hypo- or hyperthyroidism, thyroid cancer, other thyroid conditions. * Any chronic illness, including diabetes mellitus, acute or chronic infections, other disease requiring treatment. * Use of any medication or homeopathic medications. Use of paracetamol is allowed. * Smoking * Previous radioactive iodide scanning or other imaging techniques with administration of iodide containing contrast fluids within 6 months * Use of supplements that contain large quantities of iodide * Structural alcohol intake > 3 glasses/day * Subjects who have taken part in any drug trial within 3 months prior start of this study.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary endpoint is the change observed in 123I thyroid uptake measured by Radioactive iodide uptake testing (RAIU) before and after either metformin or hypocaloric dieting. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary endpoints are the changes in serum levels of TSH, fT4 and T3 before and after intervention. | — |
Countries
Netherlands
Outcome results
None listed