New Therapies for bone and cartilage defects using bone marrow

New Therapies for bone and cartilage defects using bone marrow - Bone Marrow

Status

Recruiting

Phases

Unknown

Study type

Observational

Source

NL-OMON

Registry ID

NL-OMON43408

Enrollment

200

Registered

2016-03-15

Start date

2016-08-29

Completion date

Unknown

Last updated

2024-04-23

For informational purposes only — not medical advice. Sourced from public registries and may not reflect the latest updates. Terms

Conditions

not applicable

Interventions

None listed

Eligibility

Age

18 Years to 99 Years

Inclusion criteria

Inclusion criteria: undergoing total hip replacement surgery

Exclusion criteria

Exclusion criteria: had radiation therapy in the hip area haematologic disorders (such as leukemia or hemophilia)

Design outcomes

Primary

Measure	Time frame
First the cells of interest will be isolated from the bone marrow biopsy and then subjected to a series of culture and analyses methods. The exact methods will depend on the research question. We will characterize the cells using FACS analyses and evaluate the capacity to form bone or cartilage using histology, mRNA and protein analyses. Furthermore the capacity of the cells to inhibit inflammation will be evaluated in the laboratory by bringing them in contact with immune cells. All research is aimed to find methods to improve the treatment of cartilage and bone defects.	—

Measure

Time frame

First the cells of interest will be isolated from the bone marrow biopsy and then subjected to a series of culture and analyses methods. The exact methods will depend on the research question. We will characterize the cells using FACS analyses and evaluate the capacity to form bone or cartilage using histology, mRNA and protein analyses. Furthermore the capacity of the cells to inhibit inflammation will be evaluated in the laboratory by bringing them in contact with immune cells. All research is aimed to find methods to improve the treatment of cartilage and bone defects.

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Countries

Netherlands

Outcome results