Metabolisme Energy metabolism risk factors for cardiovascular diseases
Conditions
Interventions
All subjects will receive a mixed meal including 25 grams of dried L. Barbarum
as the intervention product and a matched mixed meal without L. Barbarum as the
placebo product. The meals will be matc
Sponsors
Universiteit Maastricht
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: - Male gender - Aged between 18 and 65 years - BMI between 25-30 kg/m2 - Non-smoking - Normal triacylglycerol levels (
Exclusion criteria
Exclusion criteria: - Use of anticoagulant medication - Any medical condition that can interfere with the study judged by the principal investigator: - Usage of any kind of medication or medically prescribed diet that can interfere with the results of the study, judged by the principal investigator - Usage of antibiotics in the three weeks prior to the screening or during the study - Usage of food supplements or plant stanol/sterol enriched products in the three weeks prior to the screening and during the study - Indication of treatment according to the Standard for Cardiovascular risk management by the Dutch General Practitioners community - Participation in any other biomedical trial one month prior to the screening visit - Having donated > 150 ml blood within 1 month prior to the screening visit, planning to donate blood during the study or within one month after finishing the study - Consumption > 14 glasses alcohol per week - Reported intense sporting activities > 10 hours per week - Abuse of drugs
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| The primary outcome of this study will be postprandial energy expenditure measured with the ventilated hood system. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary study parameters are postprandial lipid and glucose oxidation, metabolic flexibility (determined as changes in the respiratory quotient), postprandial concentrations of triglycerides, apolipoprotein B48, free fatty acids, insulin, C-peptide, glucose, IL-6, TNFa, postprandial leukocyte count and differentiation and in vitro cytokine production. | — |
Countries
Netherlands
Outcome results
None listed