cardiac dysfunction in obesity
Conditions
Interventions
None listed
Sponsors
Sint Franciscus Gasthuis
Eligibility
Age
18 Years to 99 Years
Inclusion criteria
Inclusion criteria: Obesity patients undergoing bariatric surgery: BMI * 35 kg/m2, age 18-65 year and informed consent;Healthy controles: Age 18-65 years and written informed consent
Exclusion criteria
Exclusion criteria: Obesity patients undergoing bariatric surgery: Known cardiovascular disease.;Healthy controles: BMI of * 30 kg/m2, known cardiovascular disease.
Design outcomes
Primary
| Measure | Time frame |
|---|---|
| Primary Objective: To quantify the proportion of early signs of cardiac dysfunction in obese patients scheduled for bariatric surgery; To determine if obese patients scheduled for bariatric surgery have an elevated risk of (early signs of) cardiac dysfunction. This objective will be studied by comparing parameters of cardiac dysfunction in obesity patients (before bariatric surgery) with age and gender matched healthy controls. | — |
Secondary
| Measure | Time frame |
|---|---|
| Secondary Objective: To gain insight in the pathophysiology of obesity causing cardiac dysfunction . This objective will be studied by: 1. relating signs of cardiac dysfunction to specific features of obesity [inflammation, lipids, diabetes, etc.] 2. relating changes from before to one year after bariatric surgery in cardiac dysfunction and metabolic state to each other), in a longitudinal cohort study, comparing parameters of cardiac dysfunction in obesity patients before vs. 1 year after bariatric surgery, as well as the parameters associated with a change of cardiac dysfunction parameters. | — |
Countries
Netherlands
Outcome results
None listed